Sodium trifluoromethanesulfinate (CAS 2926-29-6), commonly referred to as the Langlois Reagent, is a white to off-white crystalline powder. It is a stable, solid-state source of the trifluoromethyl (CF3) radical. Unlike gaseous trifluoromethylation agents, Sodium trifluoromethanesulfinate (CAS 2926-29-6) is air-stable and can be handled without specialized equipment at room temperature. It has revolutionized the way trifluoromethyl groups are introduced into organic molecules, particularly heterocycles, under mild and environmentally friendly conditions.

• Superior Stability: An air-stable solid that is easy to weigh and store, eliminating the need for high-pressure gas handling.

• Mild Reaction Conditions: Generates CF3 radicals at room temperature using inexpensive oxidants like tert-butyl hydroperoxide (TBHP).

• Broad Functional Group Tolerance: Compatible with a wide variety of chemical structures, making it ideal for late-stage functionalization of complex molecules.

• High Efficiency: Provides excellent yields in the trifluoromethylation of electron-rich heterocycles.

• Cost-Effective: Offers a more economical and accessible route to trifluoromethylated products compared to traditional organometallic reagents.

• High Purity (greater than or equal to 98.0%): Chemfine provides electronic and pharmaceutical-grade material with strictly controlled moisture levels.

Standard industrial packaging options for Sodium trifluoromethanesulfinate include:

• 1kg or 5kg high-purity HDPE bottles for laboratory research and development.

• 25kg UN-approved fiber drums with anti-static and moisture-barrier plastic liners for industrial production.

• Custom small-volume packaging for high-value pilot testing and pharmaceutical research.

• All packaging is vacuum-sealed or nitrogen-purged to maintain the chemical activity of the sulfinate group.

Sodium trifluoromethanesulfinate should be stored in a cool, dry, and well-ventilated warehouse. Containers must be kept tightly sealed when not in use. While the product is stable under ambient conditions, it is hygroscopic and should be protected from excessive moisture and humidity. Store away from strong oxidizing agents and strong acids. Properly stored in its original, unopened container, it has a shelf life of at least 24 months.

Langlois Reagent, Trifluoromethanesulfinic acid sodium salt, Sodium CF3-sulfinate, CF3SO2Na.

1. Potassium trifluoromethanesulfinate – CAS 2926-28-5

2. Trifluoromethanesulfonic acid (TfOH) – CAS 1493-13-5

3. Sodium nonafluorobutanesulfinate – CAS 103061-00-5

4. Zinc trifluoromethanesulfinate (Ruppert-Prakash Reagent) – CAS 156150-67-1

5. Trifluoromethyl iodide (FIC-1311) – CAS 2314-97-8

6. Sodium trifluoromethanesulfonate (TfONa) – CAS 2926-30-9

7. N-Fluorobenzenesulfonimide (NFSI) – CAS 133745-75-2

8. Selectfluor – CAS 140681-55-6

9. Umemoto Reagent – CAS 106146-39-6

10. Togni Reagent – CAS 887144-97-0