• Superior stability: Stable solid at room temperature, much safer and easier to handle, store and transport than liquid borane complexes (e.g., BH3-THF)
• Guaranteed high purity: ≥98.0% minimum assay, low residual 2-methylpyridine and other impurities
• Excellent reducing performance: Highly efficient and selective reducing agent for reductive amination reactions
• Mild reaction conditions: Reacts under neutral to slightly acidic conditions, compatible with most functional groups
• Low moisture content: ≤0.5% maximum moisture, prevents premature decomposition and ensures consistent reactivity
• Strict quality control: Batch-to-batch consistency guaranteed, suitable for large-scale pharmaceutical production
• Complete documentation: Provides full technical support and regulatory documents including COA, MSDS and TDS
• Customized specifications: High purity grade (≥99.0%) available upon customer request

Borane-2-picoline complex, also known as 2-picoline borane or 2-methylpyridine borane, is a highly stable and versatile organoboron reducing agent with CAS number 3999-38-0. Its molecular formula is C6H10BN, with a molecular weight of 106.96 g/mol. Our industrial and pharmaceutical grade product appears as white to off-white crystalline powder, with strict control over purity, moisture and residual solvent content.

As one of the most widely used borane complexes, it has become the preferred reducing agent for reductive amination reactions in pharmaceutical and fine chemical industries. Unlike highly reactive and unstable liquid borane complexes, borane-2-picoline complex is a stable solid that can be handled safely under normal laboratory and industrial conditions. It exhibits excellent selectivity in reducing imines and iminium ions to amines while leaving many other functional groups intact.

Our borane-2-picoline complex is produced with advanced synthesis and purification technology, with full batch traceability and complete supporting quality documents. We can provide customized specifications and packaging to meet specific customer requirements and ensure long-term stable bulk supply for global pharmaceutical and chemical manufacturers.

FOB Reference Price: USD 55.00 - 85.00 / Kilogram (varies by purity grade)

Packaging: 25kg fiber drum with inner PE liner and nitrogen protection; 1kg/5kg aluminum foil bags for small orders; Customized packaging available upon request

MOQ: 25 Kilograms (1kg sample is available for testing and evaluation purposes)

Storage Conditions: Store in tightly sealed containers under inert gas (nitrogen/argon) atmosphere; Keep in a cool, dry, well-ventilated warehouse at 2-8℃; Avoid direct sunlight, moisture, heat sources and strong oxidizing agents; 12-month shelf life under proper storage conditions

UN Number: UN1325

Transport Hazard Class: 4.1 (Flammable Solid)

Packing Group: II

• 2-Picoline borane
• Borane 2-methylpyridine complex
• 2-Methylpyridine borane
• Borane - 2-picoline complex
• CAS 3999-38-0
• Reductive Amination Reagent
• Pharmaceutical Grade Borane Complex
• Organic Boron Reducing Agent

1. Pharmaceutical Industry (Core Application): Used as the primary reducing agent for reductive amination reactions in the synthesis of active pharmaceutical ingredients (APIs) and intermediates. It is widely employed in the production of antidepressants, antihistamines, antipsychotics and other therapeutic agents.
2. Organic Synthesis Industry: Applied as a mild and selective reducing agent for various functional groups. It reduces aldehydes and ketones to alcohols, imines to amines, and oximes to hydroxylamines under mild reaction conditions.
3. Fine Chemical Industry: Used in the synthesis of specialty chemicals, agrochemicals and functional materials. Its high selectivity allows for the production of complex molecules with minimal side reactions.
4. Material Science: Applied in the preparation of boron-containing polymers, ceramics and nanomaterials. It serves as a boron source and reducing agent in various material synthesis processes.
5. Analytical Chemistry: Used as a derivatization reagent for the analysis of carbonyl compounds and amines in environmental and biological samples.
6. Other Industrial Fields: Employed in the production of dyes, pigments and photographic chemicals.

A1: The most significant advantage is its exceptional stability. Unlike liquid borane complexes such as borane-tetrahydrofuran (BH3-THF) which are highly reactive, flammable and decompose easily, borane-2-picoline complex is a stable solid at room temperature. It is much safer to handle, store and transport, has a longer shelf life, and does not require special low-temperature storage conditions.

A2: Reductive amination reactions with borane-2-picoline complex are typically carried out in protic solvents such as methanol or ethanol at room temperature to 60℃. The reaction proceeds efficiently under neutral to slightly acidic conditions (pH 4-7). It is compatible with a wide range of aldehydes, ketones and amines, and generally provides high yields of the desired amine products.

A3: Borane-2-picoline complex is a flammable solid and reacts with water and strong acids to release flammable hydrogen gas. It should be handled in a well-ventilated area with appropriate personal protective equipment (gloves, goggles, lab coat). Store in tightly sealed containers under inert gas atmosphere to prevent contact with air and moisture. Keep away from heat sources, open flames and oxidizing agents.

A4: Yes, it is soluble in most common organic solvents including methanol, ethanol, isopropanol, tetrahydrofuran (THF), dichloromethane, chloroform and toluene. It is slightly soluble in water, but prolonged contact with water should be avoided as it will slowly decompose.

A5: Our standard industrial grade has a minimum purity of 98.0% (GC), and our pharmaceutical grade has a minimum purity of 99.0%. We strictly control key impurities including residual 2-methylpyridine (≤0.5%), moisture (≤0.5%), and other organic impurities. We can provide detailed impurity profiles upon request.